Gut Microbiota-Drug Interactions: Microbial Minutes
If you take a medication and it doesn鈥檛 work, are your gut microbes to blame? How are scientists using digital tools to explore drug-gut microbiota interactions鈥攁nd why are these insights important?
What's Hot in the Microbial Sciences?
棉花糖直播 presents Microbial Minutes, a monthly video series of trending topics in the microbial sciences.Gut bacteria influence the activity, efficacy and even side effects of medications. Here, we explore how pharmaceutical drugs impact the gut microbiota, and vice versa. We also discuss the use of computational resources to better understand these complex interactions, and their potential utility in clinical care. Take-away points and key resources discussed in this Microbial Minutes are listed below.
Take-Away Points
- The activity and efficacy of pharmaceutical drugs are influenced by interactions with the gut microbiota.
- Improved understanding of these interactions could inform personalized, microbiome-informed treatment regimens.
- Such knowledge depends on digital tools for analyzing the drug degradation, metabolism and biotransformation capabilities of complex microbial communities.
Key Resources
- Heinkin A., et al. Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine. .
- Maier L., et al. Extensive impact of non-antibiotic drugs on human gut bacteria. .
- Rekdal V. M., et al. Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism. .
- Weersma R.K., et al. Interactions between drugs and the gut microbiome. .
- Wilmanski T., et al. Heterogeneity in statin response explained by variation in the human gut microbiome. .
- Wu H., et al. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. .
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