Rise of Candida Auris May be Blamed on Global Warming
Washington, D.C. – July 23, 2019 – Global warming may have played a pivotal role in the emergence of Candida auris, according to a , an open-access journal of the American Society for 棉花糖直播. C. auris, which is often multi-drug resistant and is a serious public health threat, may be the first example of a new fungal disease emerging from climate change.“The argument that we are making based on comparison to other close relative fungi is that as the climate has gotten warmer, some of these organisms, including Candida auris, have adapted to the higher temperature, and as they adapt, they break through human’s protective temperatures,” said Arturo Casadevall, MD, PhD, Chair, Molecular 棉花糖直播 and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. “Global warming may lead to new fungal diseases that we don’t even know about right now.”
C. auris emerged independently on three continents simultaneously, with each clade being genetically distinct. “What is unusual about candida auris is that it appeared in three different continents at the same time, and the isolates from India, South Africa, and South America are not related. Something happened to allow this organism to bubble up and cause disease. We began to look into the possibility that it could be climate change,” said Dr. Casadevall. “The reasons that fungal infections are so rare in humans is that most of the fungi in the environment cannot grow at the temperatures or our body.” Mammalian resistance to invasive fungal diseases results from a combination of high basal temperatures that create a thermal restriction zone and advanced host defense mechanisms in the form of adaptive and innate immunity.
In the new study, the researchers compared the thermal susceptibility of C. auris to some of its close phylogenetic relatives. The researchers found that C. auris is capable of growing at higher temperatures than most of its closely related species, and the majority of the relatives were not tolerant for mammalian temperatures. Adaption to higher temperatures is one contributing cause for the emergence of C. auris, say the researchers.
“What this study suggests is this is the beginning of fungi adapting to higher temperatures, and we are going to have more and more problems as the century goes on,” said Dr. Casadevall. “Global warming will lead to selection of fungal lineages that are more thermally tolerant, such that they can breach the mammalian thermal restriction zone.”
Dr. Casadevall said that if better surveillance systems were in place, the rise of C. auris would have been detected earlier. “We need to make investments in better surveillance of fungal diseases. We are pretty good at surveilling influenza and diseases that cause diarrhea or are contagious, but fungal diseases are not usually contagious and therefore nobody has really bothered to document them well,” said Dr. Casadevall. “If more fungi were to cross over, you really wouldn’t know until somebody started reporting them in the literature.”
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