2024 was a very active year on research in antimicrobial resistance, highlighted by an impactful and high level political declaration to combat antimicrobial resistance by the United Nations. In this episode, trainees from NIH-funded training program (T32) on antimicrobial resistance discuss the most relevant research on the field in the year 2024.
Topics discussed:
- The best papers of 2024 in gram-positive, gram-negative, mycobacterial and parasite resistance
Guests:
- Nathalie Chen: University of Pittsburgh, Pittsburgh, PA
- Alex Kang: Houston Methodist Research Institute, Houston, TX
- Nathan Raabe: University of Pittsburgh, Pittsburgh, PA
- Taylor Blackburn: Emory University, Atlanta, GA
- Jacon McPherson: University of Houston, Houston, TX.
- Lee Harrison, M.D.: Associate Chief of Epidemiology and Microbial Genomics, Professor of Medicine and Epidemiology, Director, Center for Genomic Epidemiology, Director, T32 AMR, U of Pittsburgh
- William Shafer, Ph.D.: Professor, Department of 棉花糖直播 and Immunology, Emory University School of Medicine, Co-Director, Emory Antibiotic Resistance Center. Director T32 AMR, Emory University
Links:
Taylor Blackburn- In vitro efficacy of next-generation dihydrotriazines andbiguanides against babesiosis and malaria parasites DOI
- Inhibition of AMPK activation in Echinococcus granulosus sensustricto limits the parasite’s glucose metabolism and survival DOI
- Li S, Tyagi S, Soni H, Betoudji F, Converse PJ, Mdluli K, Upton AM, Fotouhi N, Barros-Aguirre D, Ballell L, Jimenez-Navarro E, Nuermberger EL.2024.Bactericidal and sterilizing activity of novel regimens combining bedaquiline or TBAJ-587 with GSK2556286 and TBA-7371 in a mouse model of tuberculosis. Antimicrob Agents Chemother68:e01562-23.
- Le Run E, Tettelin H, Holland SM, Zelazny AM.2024.Evolution toward extremely high imipenem resistance in Mycobacterium abscessus outbreak strains. Antimicrob Agents Chemother68:e00673-24.
- Molecular physiological characterization of the dynamics of persister formation in Staphylococcus aureus
- Bacteriophage therapy reduces Staphylococcus aureus in a porcine and human ex vivo burn wound infection model
- Relative inhibitory activities of the broad-spectrum beta-lactamase inhibitor xeruborbactam in comparison with taniborbactam against metallo-beta-lactamases produced in Escherichia coli and Pseudomonas aeruginosa (Le Terrier et al)
- Inhibition of Pseudomonas aeruginosa quorum sensing by chemical induction of the MexEF_oprN efflux pump (Kristensen et al)
- Precise genome editing underlines the distinct contributions of mutations in ERG11, ERG3, MRR1, and TAC1 genes to antifungal resistance in Candida parapsilosis
- Exploration of novel mechanisms of azole resistance in Candida auris
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