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Dr. Seshu's research focus is to study how pathogenic bacteria interact with their hosts leading to infectious diseases such as Lyme disease and Q fever. The lab has started studies on how antibiotic-resistant strains of bacteria influence physiological responses critical for healing of infected wounds. They determined the role of key players in regulatory pathways that facilitate bacterial pathogens to adapt to different environmental conditions and devise strategies to interfere with the lifestyles of bacteria to prevent their infectious capabilities.

The lab also focuses on developing a variety of products such as vaccines, inhibitors of critical metabolic pathways, and modulators of host response to prevent bacterial infections using a number of experimental models of infection in conjunction with state-of-the-art methods in genomics, proteomics, and metabolomics of host-pathogen interactions.